Pentapeptide-18 (Leuphasyl) Topical (200mg)

Pentapeptide-18 (Leuphasyl) Topical (200mg) is a lyophilized research peptide synthesized, purified, and lyophilized in the USA. Each production batch is purified by repeated rounds of reverse-phase HPLC and identity-confirmed by mass spectrometry.

Current evaluation of Pentapeptide-18 (Leuphasyl) Topical (200mg) explores its compatibility with common formulation excipients used in cosmetic research.

Pentapeptide-18 (Leuphasyl) Topical (200mg) is a cosmetic-research peptide evaluated in formulations for its signaling effects on skin-related cell models.

Studies of Pentapeptide-18 (Leuphasyl) Topical (200mg) typically focus on collagen-related or matrix-associated endpoints in dermal cell cultures.

Each vial contains lyophilized peptide at the labeled quantity, and wholesale orders are packed in boxes of ten vials at a single per-vial price.

Quality assurance: every batch is purified by reversed-phase high-performance liquid chromatography and identity-confirmed by mass spectrometry, with purity above 99%. Lot-specific certificates of analysis are available on request. Store lyophilized vials at -20°C, protected from light and moisture; reconstitute with bacteriostatic water immediately before use and avoid repeated freeze-thaw cycles. For in-vitro laboratory research use only —not for human or veterinary use.

Research & Literature

The following peer-reviewed studies and reference documents are commonly consulted by researchers working with Pentapeptide-18 (Leuphasyl) Topical (200mg). Summaries are provided for orientation only and reflect the cited sources.

Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18 - Optimization, Characterization, and Cosmetic Application^[1] —This study optimized solid lipid nanoparticles incorporating retinol and pentapeptide-18 (Leuphasyl) and characterized the resulting formulations. The authors evaluated the nanoparticles' stability and suitability for cosmetic application. The findings confirmed that the nanocarrier system can stably co-deliver retinol and pentapeptide-18 for anti-aging use. (International Journal of Molecular Sciences 2024)

Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies^[2] —This study investigated lipid nanocarriers loaded with retinol and oligopeptides, including pentapeptide-18, as raw materials for anti-acne and anti-aging therapies. The authors examined effects such as sebum secretion and wrinkle formation in an in vivo model. The results suggested that the loaded nanocarriers reduced sebum and facial wrinkles while limiting retinol irritation. (Life 2024)

D-tyrosine adds an anti-melanogenic effect to cosmetic peptides^[3] —This study explored whether adding D-tyrosine at the terminal position confers anti-melanogenic activity to cosmetic peptides, including pentapeptide-18. The authors tested the modified peptides in melanocytes and a three-dimensional human skin model. The findings indicated that the D-tyrosine-modified pentapeptide-18 gained the ability to inhibit melanin production. (Scientific Reports 2020)

References

1. Pawlowska M, Marzec M, Jankowiak W, Nowak I. "Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18 - Optimization, Characterization, and Cosmetic Application." International Journal of Molecular Sciences. 2024. pmc.ncbi.nlm.nih.gov/articles/PMC11432460/pdf/ijms-25-10078.pdf
2. Pawlowska M, Marzec M, Jankowiak W, Nowak I. "Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies." Life. 2024. pmc.ncbi.nlm.nih.gov/articles/PMC11508827/pdf/life-14-01212.pdf
3. Park J, Jung H, Jang B, Song HK, Han IO, Oh ES, Kim SH, Lee JY. "D-tyrosine adds an anti-melanogenic effect to cosmetic peptides." Scientific Reports. 2020. pubmed.ncbi.nlm.nih.gov/31937863/

All products are supplied as lyophilized powder for in-vitro laboratory research use only and are not for human or veterinary use.