SLU-PP-332 (5mg & 10mg)

SLU-PP-332 is a synthetic estrogen-related receptor (ERR) agonist studied in metabolic and energy-expenditure research models, supplied as a lyophilized powder for in-vitro laboratory research use. Purity specification: above 99% (HPLC-MS). For in-vitro research use only.

SLU-PP-332 (5mg & 10mg) serves as a research tool for examining the interplay between peptide signaling and metabolic endpoints in experimental designs.

Laboratory programs frequently validate SLU-PP-332 (5mg & 10mg) with HPLC purity checks and mass confirmation before assay work begins.

SLU-PP-332 (5mg & 10mg) is commonly included in metabolic research panels investigating appetite-regulating pathways and energy homeostasis in laboratory models.

This product is available in 5mg and 10mg. Each vial contains lyophilized peptide at the labeled quantity; wholesale orders are packed in boxes of ten vials at a single per-vial price.

Quality assurance: every batch is purified by reversed-phase high-performance liquid chromatography and identity-confirmed by mass spectrometry, with purity above 99%. Lot-specific certificates of analysis are available on request. Store lyophilized vials at -20°C, protected from light and moisture; reconstitute with bacteriostatic water immediately before use and avoid repeated freeze-thaw cycles. For in-vitro laboratory research use only —not for human or veterinary use.

Research & Literature

The following peer-reviewed studies and reference documents are commonly consulted by researchers working with SLU-PP-332 (5mg & 10mg). Summaries are provided for orientation only and reflect the cited sources.

Synthetic ERRalpha/beta/gamma Agonist Induces an ERRalpha-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity^[1] —This study identified and characterized SLU-PP-332 as a synthetic agonist of the estrogen-related receptors ERRα, ERRβ, and ERRγ. The compound was reported to induce an ERRα-dependent acute aerobic exercise-like transcriptional response and to enhance exercise capacity in mice. The findings position SLU-PP-332 as a prototype exercise mimetic targeting the ERR pathway. (ACS Chemical Biology 2023)

Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study^[2] —This pilot study explored whether targeting estrogen-related receptors could counteract age-related muscle atrophy associated with physical inactivity. Using cells from inactive women, the authors reported that ERR targeting elicited metabolic and gene-expression changes supportive of counteracting disuse-related muscle decline. The results suggest ERR modulation as a potential strategy against inactivity-induced muscle loss. (Frontiers in Physiology 2025)

Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity^[3] —This study examined the role of estrogen-related receptor gamma (ERRγ) in skeletal muscle metabolic regulation. The authors demonstrated that ERRγ regulates mitochondrial and oxidative gene expression, thereby controlling muscle oxidative capacity. These findings provided mechanistic support for targeting the ERR family in the development of exercise mimetics such as SLU-PP-332. (Journal of Biological Chemistry 2010)

References

1. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. "Synthetic ERRalpha/beta/gamma Agonist Induces an ERRalpha-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity." ACS Chemical Biology. 2023. pubmed.ncbi.nlm.nih.gov/36988910/
2. Bonanni R, Falvino A, Matticari A, Rinaldi AM, D'Arcangelo G, Cifelli P, Iundusi R, Gasbarra E, Tancredi V, Cariati I, Tarantino U. "Targeting ERRs to counteract age-related muscle atrophy associated with physical inactivity: a pilot study." Frontiers in Physiology. 2025. public-pages-files-2025.frontiersin.org/journals/physiology/articles/10.3389/fphys.20—
3. Rangwala SM, Wang X, Calvo JA, Lindsley L, Zhang Y, Deyneko G, Beaulieu V, Gao J, Turner G, Markovits J. "Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity." Journal of Biological Chemistry. 2010. pubmed.ncbi.nlm.nih.gov/20418374/

All products are supplied as lyophilized powder for in-vitro laboratory research use only and are not for human or veterinary use.