MOTS-C (10mg, 20mg, 30mg, 40mg)

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, with the sequence MRWQEMGYIFYPRKLR (CAS 1627580-64-6). It is synthesized, purified by repeated rounds of reversed-phase HPLC, and identity-confirmed by mass spectrometry in the USA, then supplied as a lyophilized powder.

In the published literature, MOTS-c is studied as a mitochondrial-derived signaling peptide. The landmark 2015 Cell Metabolism report described MOTS-c as activating AMPK-linked metabolic pathways through the folate-cycle/purine-biosynthesis axis, and examined glucose uptake and metabolic-homeostasis readouts in cellular and rodent models. It is frequently included alongside other mitochondrial peptides in standardized metabolic and aging-research panels.

This listing offers four labeled strengths —10mg, 20mg, 30mg, and 40mg per vial —so a laboratory can run a dose-response series from a single product without reordering. Select the required size above; every strength is sold by the box of ten vials at a fixed per-vial rate.

Quality assurance: every batch is purified by reversed-phase high-performance liquid chromatography and identity-confirmed by mass spectrometry, with purity above 99%. Lot-specific certificates of analysis are available on request. Store lyophilized vials at -20°C, protected from light and moisture; reconstitute with bacteriostatic water immediately before use and avoid repeated freeze-thaw cycles.

Research & Literature

The following peer-reviewed studies and reference documents are commonly consulted by researchers working with MOTS-C. Summaries are provided for orientation only and reflect the cited sources.

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance^[1] —This landmark study identified MOTS-c as a peptide encoded in the mitochondrial genome. The authors report that MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance in mice. These findings established MOTS-c as a mitochondrial-derived signal with relevance to metabolic regulation. (Cell metabolism 2015)

MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide^[2] —This study characterized MOTS-c as a mitochondrial-encoded peptide with host defense functions. The authors report that MOTS-c behaves as an interferon-linked peptide involved in innate immune signaling. The findings expand the known biological roles of MOTS-c beyond metabolism. (eLife 2026)

Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review^[3] —This systematic review examined mitochondrial-derived peptides (MDPs) that are activated by physical exercise and their potential as therapeutic targets for metabolic disorders. The authors synthesize evidence on how exercise-regulated MDPs may influence metabolic health. MOTS-c is considered within this broader class of mitochondrial peptides. (Physiology international 2026)

MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases^[4] —This review discusses how the secreted mitochondrial microprotein MOTS-c may become a potential treatment for inflammatory lung diseases. The authors explore the peptide's anti-inflammatory and metabolic properties in the context of pulmonary pathology. The article outlines directions for future translational research on MOTS-c. (Journal of translational medicine 2026)

References

1. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." Cell metabolism. 2015. pubmed.ncbi.nlm.nih.gov/25738459/
2. Rice MC, Imun M, Jung SW, Park CY, Kim JS, Lai RW, Barr CR, Son JM, Tor K, Kim E, Lu RJ, Cohen I, Benayoun BA, Lee C. "MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide." eLife. 2026. pubmed.ncbi.nlm.nih.gov/42611943/
3. Ayubi N, Wibawa JC, Kurnaz M, Komaini A. "Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review." Physiology international. 2026. pubmed.ncbi.nlm.nih.gov/42640735/
4. Amado CA, Agüero J, García-Unzueta M, Berja A, Lavín BA, Martín-Audera P. "MOTS-c: How a secreted mitochondrial microprotein may become a potential treatment for inflammatory lung diseases." Journal of translational medicine. 2026. pubmed.ncbi.nlm.nih.gov/42243958/